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A three-dimensional model for the evaluation of the
global effect of the shear field on a cell’s surface
Autori: M. Grigioni, C. Daniele, G. D’Avenio, C. Del Gaudio, U. Morbiducci,
M. Abbate, V. Barbaro
Presentato al: VIII Convegno Nazionale di Reologia
Anno: 2004
Volume: Unico
Issue: Unico
Casa Editrice:
Lingua: English
Abstract
Blood components can be damaged by fluid shear stresses, especially those present downstream of artificial devices. Reynolds shear stresses have been found to be positively correlated with hemolysis and sublethal damage to red blood cells (RBCs) and platelets. Currently, the evaluation of the lytic potential to cells, associated to a given flow field, is focused on the highest value of shear stress acting locally. It can be supposed that also the superposition of the loading contributions on each surface element of a cell is important in determining the response of the latter to the shear field. We present the results of a numerical study, which enabled us to calculate the threedimensional shear field on the surface of an ellipsoid, i.e., the simplified model of a blood constituent. An evaluation parameter (the squared shear stress integrated over the surface) is presented for the global load on the cell. As opposed to the simple case of a spherical cell, the eccentricity of the ellipsoidal geometry is seen to have important consequences, in that the orientation of the major axis determines remarkable changes in the global value of the loading imparted by the fluid forces.
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