|
|
|
|
|
|
|
|
A mathematical method to quantify the effect of
helical flow on endothelial cells
Autori: M. Grigioni, C. Daniele, U. Morbiducci, C. Del Gaudio, G. D’Avenio,
M. Abbate, V. Barbaro
Presentato al: VIII Convegno Nazionale di Reologia
Anno: 2004
Volume: Unico
Issue: Unico
Casa Editrice:
Lingua: English
Abstract
Over the last years, several investigations have pointed to the key role of flow in influencing the vascular endothelium. In blood vessels, the extracellular matrix underlying the endothelium supports endothelial cell attachment, spreading, migration, and proliferation. A significant role is played by shear stress-induced alterations in the endothelial function, e.g., in the initiation of atherosclerotic lesions. Helical flow may play both a detrimental and a beneficial role, e. g., in plaque deposition, organ perfusion or in the tuning of cells’ mechanotrasduction pathways. The presence of the rotational component in helical flow must be accounted for in studies of endothelial shear. The proposal that mechanical forces play a role in the localization of the dysfunctional state of the vascular endothelium led us to develop a mathematical method to quantify the helical flow contents in a flow field, with the aim to furnish a synthetic tool to approach specific correlations between specific flow patterns and endothelial cells migration and proliferation. As a perspective, the proposed method could be used for the improvement of the cell seeding of prostheses by bioreactors.
Attenzione la lettura completa dell'Abstract e il download dei file è riservata esclusivamente ai Soci dell'Associazione Italiana di Reologia.
Se sei un Socio ti preghiamo di effettuare il login se non lo hai già fatto
Nel caso non fossi un Socio dell'Associazione Italiana di Reologia ti preghiamo di visitare la sezione "Iscriviti all'Associazione" per procedere alla registrazione
|
|
|
|
|
|
|
|
|
|
|
|
|