A mathematical method to quantify the effect of helical flow on endothelial cells

Autori: M. Grigioni, C. Daniele, U. Morbiducci, C. Del Gaudio, G. D’Avenio, M. Abbate, V. Barbaro
Presentato al: VIII Convegno Nazionale di Reologia
Anno: 2004
Volume: Unico
Issue: Unico
Casa Editrice:
Lingua: English


Abstract
Over the last years, several investigations have pointed to the
key role of flow in influencing the vascular endothelium. In blood vessels,
the extracellular matrix underlying the endothelium supports
endothelial cell attachment, spreading, migration, and proliferation.
A significant role is played by shear stress-induced alterations in the
endothelial function, e.g., in the initiation of atherosclerotic lesions.
Helical flow may play both a detrimental and a beneficial role, e. g., in
plaque deposition, organ perfusion or in the tuning of cells’ mechanotrasduction
pathways. The presence of the rotational component in
helical flow must be accounted for in studies of endothelial shear. The
proposal that mechanical forces play a role in the localization of the
dysfunctional state of the vascular endothelium led us to develop a
mathematical method to quantify the helical flow contents in a flow
field, with the aim to furnish a synthetic tool to approach specific correlations
between specific flow patterns and endothelial cells migration
and proliferation. As a perspective, the proposed method could be
used for the improvement of the cell seeding of prostheses by bioreactors.


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